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Abstract In this work, we report the regiospecific and stereoselective synthesis of novel pyrrolo thioxoimidazolidinones with promising biological activities due to the inherent pharmaceutical properties of thioxoimidazolidinone core. The reaction of different thioxoimidazolidinones withtrans‐4‐ethoxy‐1,1,1‐trifluorobut‐3‐en‐2‐one (ETFBO) yields bicyclic 1,3‐diaza heterocycles bearing the trifluoromethyl (CF₃) moiety. Our investigation involved both depth experimental analysis and theoretical calculations to fathom out the mode of reaction of this building block and elucidate the underlying mechanism operating for the observed reactions. Remarkably, this unusual mechanism retained the ethanol moiety from the building block in the final products, deviating from conventional nucleophilic reactions reported in the literature. 

The Milky Way’s Central Molecular Zone (CMZ) differs dramatically from our local solar neighbourhood, both in the extreme interstellar medium conditions it exhibits (e.g. high gas, stellar, and feedback density) and in the strong dynamics at play (e.g. due to shear and gas influx along the bar). Consequently, it is likely that there are large-scale physical structures within the CMZ that cannot form elsewhere in the Milky Way. In this paper, we present new results from the Atacama Large Millimeter/submillimeter Array (ALMA) large programme ACES (ALMA CMZ Exploration Survey) and conduct a multi-wavelength and kinematic analysis to determine the origin of the M0.8–0.2 ring, a molecular cloud with a distinct ring-like morphology. We estimate the projected inner and outer radii of the M0.8–0.2 ring to be 79″ and 154″, respectively (3.1 pc and 6.1 pc at an assumed Galactic Centre distance of 8.2 kpc) and calculate a mean gas density >10⁴cm⁻³, a mass of ~10⁶M_⊙, and an expansion speed of ~20 km s⁻¹, resulting in a high estimated kinetic energy (>10⁵¹erg) and momentum (>10⁷M_⊙km s⁻¹). We discuss several possible causes for the existence and expansion of the structure, including stellar feedback and large-scale dynamics. We propose that the most likely cause of the M0.8–0.2 ring is a single high-energy hypernova explosion. To viably explain the observed morphology and kinematics, such an explosion would need to have taken place inside a dense, very massive molecular cloud, the remnants of which we now see as the M0.8–0.2 ring. In this case, the structure provides an extreme example of how supernovae can affect molecular clouds.